RecruitingNot ApplicableNCT06845722

Combined Effects of Balance and Cognitive Training in Patients With Multiple Sclerosis

Combined Effects of Balance and Cognitive Training on Executive Functions, Balance and Quality of Life in Patients With Multiple Sclerosis

Sponsor

Riphah International University

Enrollment

42 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis

Summary

Multiple sclerosis is a potentially disabling disease of the brain and spinal cord involving the central nervous system. Multiple Sclerosis can cause balance and cognitive impairment in patients, affecting overall quality of life. Balance and cognitive training can effectively improve the overall executive function and mobility in patients with multiple sclerosis.

Eligibility

Min Age: 40 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining balance training with cognitive (thinking and memory) exercises is more effective than balance training alone in improving physical stability and thinking skills in people with multiple sclerosis (MS). **You may be eligible if...** - You are between 40 and 55 years old with a confirmed diagnosis of multiple sclerosis (any form: relapsing-remitting, primary progressive, or secondary progressive) - You have mild cognitive difficulties (a specific score on the MoCA memory test) - You have balance problems (a specific score on the Berg Balance Scale) - You have difficulty with walking **You may NOT be eligible if...** - You have had a moderate to severe head injury - Your cognitive or balance difficulties are severe enough to prevent participation - You have other neurological conditions that could affect the results Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBalance training

* The balance training will be given for 12 weeks (2 sessions/week, 30-35 in each) that included six balance exercises per training session. * After 5-min warm-up program including general (e.g., neck rolls, shoulder circles, side bends, hip circles, marsh in place) and specific (e.g., two-/one-legged stance on unstable devices, forward/backward beam walking). * Two sets per balance exercise will be performed for 30s each with a 60s rest period between sets and a 90 s break between exercises. Yet, both groups will execute the same training volume (i.e., number of exercises, number of sets per exercise, and duration per set of exercise). * Progression during training will be achieved by means of increasing exercise duration (i.e., from 30s over 45s to 60 s), change of stance (i.e., two-legged stance, tandem. stance, one-legged stance) and walking (i.e., forward, backward) condition, manipulation of visual input (e.g., eyes opened vs. closed), and concurrent execution of cognitive

OTHERCognitive Rehabilitation:

* The cognitive rehabilitation will be given for 12 weeks ( 2 sessions/week,30 min each session). The individual sessions for the CR approach will involve an individualized intervention focusing on a personally meaningful goal (e.g., maintaining attention while flipping cards and finding matching pairs, learning to use a cellular phone, remembering the names of people). * The individual sessions will be consisted of practical strategies and aids, compensation strategies (e.g., using a memory notebook), and the techniques for stress management to improve performance and functioning in relation to goals. The group sessions of CR involved some tasks of cognitive training. * The group sessions will be focused on practicing time-and-place orientation through paper-and pencil tasks provided by a therapist and use of a calendar and personal memory notebook or cellular phone at the start of each session. (30) * The group sessions also involved matching faces and names and learning memory