RecruitingPhase 2Phase 3NCT06851663

Trop2-targeted immunoPET Imaging of Solid Tumors


Sponsor

RenJi Hospital

Enrollment

400 participants

Start Date

Dec 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to establish and optimize the trophoblast cell surface antigen 2 (Trop2)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging method and its physiological and pathological distribution characteristics, based on which the diagnostic efficacy of the above imaging agents in solid tumors (including uroepithelial cancer, bladder cancer, prostate cancer, lung cancer, nasopharyngeal cancer, liver cancer, cholangiocarcinoma, ovarian cancer, cervical cancer, endometrial cancer, thyroid cancer, head and neck cancer) will be evaluated.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of PET scan imaging that uses a radiotracer targeting Trop2 — a protein overexpressed on many cancer types — to non-invasively detect and measure Trop2 expression in solid tumors, which could help guide treatment decisions for Trop2-targeted therapies. **You may be eligible if...** - You are between 18 and 75 years old - You have a confirmed or suspected solid tumor, including cancers of the bladder, prostate, lung, nasopharynx, liver, bile ducts, ovaries, cervix, uterus, thyroid, or head and neck - You are able to undergo a PET scan - You have provided written informed consent **You may NOT be eligible if...** - You have a cancer type not listed among the eligible solid tumors - You have significant kidney problems that would make the imaging agent unsafe - You are pregnant or breastfeeding - You have previously had a severe allergic reaction to similar imaging agents Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG[68Ga]Ga-NOTA-T4

Enrolled patients will receive 0.05-0.1 mCi/kg of \[68Ga\]Ga-NOTA-T4. ImmunoPET/CT imaging will be acquired 1-2 hours after \[68Ga\]Ga-NOTA-T4 injection.

DRUG[68Ga]Ga-NOTA-RT4

Enrolled patients will receive 0.05-0.1 mCi/kg of \[68Ga\]Ga-NOTA-RT4. ImmunoPET/CT imaging will be acquired 1-2 hours after \[68Ga\]Ga-NOTA-RT4 injection.

DRUG[18F]F-RESCA-T4

Enrolled patients will receive 0.05-0.1 mCi/kg of \[18F\]F-RESCA-T4. ImmunoPET/CT imaging will be acquired 1-2 hours after \[18F\]F-RESCA-T4 injection.

DRUG[18F]F-RESCA-RT4

Enrolled patients will receive 0.05-0.1 mCi/kg of \[18F\]F-RESCA-RT4. ImmunoPET/CT imaging will be acquired 1-2 hours after \[18F\]F-RESCA-RT4 injection.


Locations(1)

Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, China

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NCT06851663


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