Training Cognition With Neurofeedback After Stroke
Cognitive Impairment Mechanisms and Training With Real Time-functional MRI Neurofeedback After Stroke
University Hospital, Bordeaux
20 participants
Feb 28, 2025
INTERVENTIONAL
Conditions
Summary
Post-stroke cognitive impairment (PSCI) is a common source of invisible disability. The actual techniques of cognitive remediation have been reported to have only a small effect, justifying the need to foster research in this field. Real-time functional MRI neurofeedack (rt-fMRI NF) is a procedure of brain-machine interface supporting self-regulation of brain activity, with promising results in the treatment of mental disorders. The main objective of the study is to evaluate in a pilot study, the ability of stroke patients to learn to self-regulate their brain activity in a priviledged direction, using rt-fMRI NF
Eligibility
Inclusion Criteria11
- Men or women
- Right handed
- ≤ years old < 75
- first-ever ischemic stroke on brain MRI in the past 3 to 6 months ;
- Persisting cognitive complaint 3 months after the ischemic stroke, proved by a MoCA score ≤ 26 (if educational level ≥ 12 years, or ≤ 25 if educational level < 12 years), and involving at least one of the following cognitive domains : executive functions, attention, and processing speed ;
- Ischemic stroke located in the territory of the middle cerebral artery and /or basal ganglia/thalamus ;
- NIHSS ≤ 5, without aphasia or severe visual disability empeding the understanding of the instructions, the neurofeedback task achievement, and/or the neuropsychological assessment ;
- No prestroke disability defined by a modified Rankin Scale ≤ 2 ;
- For women of childbearing potential, use of effective contraception and negative pregnancy test.
- Written informed consent by the patient.
- Coverage by the French Social Insurance
Exclusion Criteria11
- Previous cognitive impairment ;
- History of psychiatric disorder ;
- Current use of psychotropic medication ;
- MRI contraindication ;
- Pregnancy or breastfeeding ;
- Chronic disease empeding the follow-up of the subject during the lenght of the study ;
- Non fluently-French speakers ;
- Patient under legal protection.
- Patient unable of giving personal consent
- Emergency situation
- st MRI incomplete, not performed or not analyzable
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Interventions
Cognitive remediation therapy as treatment as usual
Neuropsychological assessment to measure cognitive performances
Real-time functional MRI neurofeedack (rt-fMRI NF) is a procedure of brain-machine interface supporting self-regulation of brain activity, with promising results in the treatment of mental disorders. The main objective of the study is to evaluate in a pilot study, the ability of stroke patients to learn to self-regulate their brain activity in a priviledged direction.
fMRI sessions but without receiving feedback
Locations(1)
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NCT06852209