RecruitingNCT06857994

The Association Between Cognitive Function and Neuropathy in Individuals With Type 2 Diabetes

The Association Between Cognitive Function and Diabetic Neuropathy in Individuals With Type 2 Diabetes

Sponsor

Steno Diabetes Center Copenhagen

Enrollment

96 participants

Start Date

Mar 10, 2025

Study Type

OBSERVATIONAL

Conditions

Cognitive Impairment Peripheral Diabetic Neuropathy Diabetes Type 2 Cardiovascular Autonomic Neuropathy

Summary

The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to investigate the potential reasons for this association. The primary research question is: Is diabetic peripheral and cariovascular autonomic neuropathy in type 2 diabetes associated with cognitive decline? To address this question, the study will include individuals with and without type 2 diabetes. All participants will undergo comprehensive neuropathy assessments, neuropsychological evaluations and blood biomarker analysis. In addition, some individuals will undergo structural and functional brain MRI.

Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the relationship between thinking and memory problems (cognitive function) and nerve damage in the feet and legs (peripheral neuropathy) in older adults with Type 2 diabetes, comparing them with people who do not have diabetes. **You may be eligible if...** - You are 65 years or older - You have had Type 2 diabetes for more than 5 years (and meet other metabolic criteria), OR you have no diabetes diagnosis - Your BMI is 35 or below (for those with diabetes) - Your diabetes treatment has been stable for at least 8 weeks - You speak and understand Danish (required for cognitive testing) **You may NOT be eligible if...** - You have a condition that would make it unsafe or invalid to participate in cognitive or nerve function testing (check with your doctor for specifics) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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