NoPro - Norwegian Hernia Prophylaxis Study
NoPro - Norwegian Hernia Prophylaxis Study: Onlay Mesh Versus Small Bite Suture Technique Closure of Midline Laparotomies
Sykehuset Innlandet HF
150 participants
Feb 17, 2025
INTERVENTIONAL
Conditions
Summary
A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh. The primary endpoint is the incidence of incisional hernias in both groups after one year.
Eligibility
Inclusion Criteria4
- Surgery predominantly done my midline laparotomy
- Age 18 years old or older
- Written consent by patient/family
- Midline laparotomy with delayed closure
Exclusion Criteria7
- Age under 18 years
- Pregnancy
- Previous abdominal midline hernia mesh repair
- Abdominal compartment syndrome
- Linea alba closure not possible
- Life expectancy under six months
- Hernia in the midline with transverse diameter lager than 2 cm
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Interventions
The patients in the mesh group are closed with small bites technique and in addition receiving an onlay polypropylene mesh when closing the fascia in midline laparotomies.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06858020