CARPEUS : Effect of Carvedilol on the Portosystemic Gradient as Measured by Endoscopic Ultrasound

This study is testing whether a blood pressure drug called carvedilol can reduce high pressure in the portal vein (the large vein that carries blood to the liver) in people with liver cirrhosis, measured using a new ultrasound-based technique during an endoscopy procedure. **You may be eligible if...** - You are 18 or older - You have cirrhosis (scarred liver) and suspected high blood pressure in your liver's portal vein - You have signs of portal hypertension on imaging or liver stiffness measurements - You do not currently take carvedilol or a similar beta-blocker **You may NOT be eligible if...** - You already take carvedilol or another non-selective beta-blocker - You have a condition that prevents you from taking beta-blockers (e.g., severe asthma, very slow heart rate, severe low blood pressure) - You have active or recent internal bleeding Talk to your doctor to see if this trial is right for you.