RecruitingNot ApplicableNCT06870500

Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient

Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient and Its Relation With Response to Methotrexate

Sponsor

South Valley University

Enrollment

50 participants

Start Date

Mar 5, 2025

Study Type

INTERVENTIONAL

Conditions

Psoriatic Arthritis

Summary

Psoriasis is a chronic, immune-mediated, multisystemic, inflammatory disease caused by the interaction of multiple susceptibility genes and environmental factors that affects 1-3% of the population worldwide .Psoriasis also is a chronic inflammatory skin disease characterized by scaly indurated erythema. Psoriatic arthritis (PsA) is an autoimmune and chronic musculoskeletal disorder that is associated with psoriasis of the skin . Its presentation can vary from subtle manifestations to highly destructive forms. Joint pain, stiffness and swelling are the most common symptoms.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria2

Patients aged 18 years and above.
Patients having psoriasis diagnosed clinically and who have a severity grade of moderate to severe, defined as a Psoriasis Area and Severity Index (PASI) score from 5- 10 % of body surface area, and involvement of greater than 10% of the body surface area (BSA) with or without psoriatic arthritis

Exclusion Criteria7

Patients with other autoimmune conditions (e.g., rheumatoid arthritis, systemic lupus erythematosus).
Pregnancy and lactation.
Patients currently undergoing immunosuppressive or systemic therapies.
Patients with known genetic disorders affect immune system function.
Patients with liver or kidney impairment.
Patients with allergy or contraindication to methotrexate.
Patients with active or uncontrolled infections, including chronic infections like tuberculosis.

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Interventions

DRUGMethotrexate

1. Assess the response of psoriasis and psoriatic arthritis to Methotrexate. 2. Assess the relation between Card14 gene(rs 34367357 ) Polymorphism in psoriatic and psoriatic arthritis patients and their clinical response to methotrexate

DRUGPlacebo

Placebo