The Locus Coeruleus, Norepinephrine and Cognitive Aging

This study looks at the locus coeruleus — a small brain region that produces norepinephrine (a key brain chemical) — and how it changes with age and contributes to cognitive decline (thinking and memory problems). Using MRI brain scans and cognitive testing, researchers aim to understand why some people age better cognitively than others. **You may be eligible if:** - You are 18 or older - You can speak and understand English - Your hearing and vision are normal or correctable - You are comfortable using a touchscreen, keyboard, and mouse - You are willing and able to have an MRI scan at the Cornell MRI Facility **You may NOT be eligible if:** - You have metal implants or other factors that make MRI unsafe (e.g., pacemakers, certain implants) - You are claustrophobic to a degree that prevents MRI - You cannot complete the cognitive or computer-based assessments - You have a neurological condition that would confound the study results Talk to your doctor to see if this trial is right for you.