A Phase 2 Study Evaluating the Safety and Efficacy of JS207 With or Without JS015 in Combination With Chemotherapy in Patients With Colorectal Cancer

This Phase 2 study is testing a combination of two experimental drugs — JS207 and JS015 — together with chemotherapy in people with advanced (stage IV) colorectal cancer that has not been treated with systemic therapy before, and specifically in tumors with a genetic profile called MSS/pMMR (which historically does not respond well to immunotherapy alone). **You may be eligible if...** - You are between 18 and 75 years old - You have stage IV colorectal or rectal adenocarcinoma confirmed by biopsy - Your tumor is MSS or pMMR (a specific genetic type) - You have not had prior systemic treatment for advanced disease (adjuvant therapy more than 12 months ago may be acceptable) - Your cancer is measurable on imaging - You are in good overall health (ECOG 0 or 1) **You may NOT be eligible if...** - You have previously received PD-1/PD-L1 or DKK1 inhibitor therapy - You are pregnant or breastfeeding - You have significant heart, liver, or autoimmune conditions Talk to your doctor to see if this trial is right for you.