RecruitingNot ApplicableNCT06896227

TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics

Transcatheter Aortic Valve Implantation (TAVR): The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics


Sponsor

Heinrich-Heine University, Duesseldorf

Enrollment

100 participants

Start Date

Oct 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this clinical study is to learn more about the effects of TAVR-prosthesis positioning on hemodynamics and the coronary arteries. The main questions it aims to answer are: 1. Does the cardiac magnetic resonance imaging and the echocardiography imaging provide an equivalent alternative to the computer tomography which is the state of the art in evaluating commissural alignment? 2. What effect does the position of the valve on the annular level have, especially its symmetrical and commissural position, on valvular and aortic blood flow characteristics? 3. What is the influence of symmetrical position and the presence of a commissural alignment on the coronary flow after transcatheter aortic valve replacement?


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is looking at how the position of an artificial heart valve placed through a catheter (a TAVR procedure — transcatheter aortic valve replacement) affects blood flow through the valve and to the coronary arteries (the arteries that supply the heart muscle). By analyzing imaging data from patients who have already had the procedure, researchers hope to learn how valve positioning can be optimized to reduce future complications. **You may be eligible if...** - You have already undergone a TAVR procedure with the valve placed through the groin (transfemoral approach) - Your medical records and imaging data are available for analysis **You may NOT be eligible if...** - Your valve was placed through a route other than the groin (e.g., through the chest or arm) - You had a valve placed inside a previously implanted bioprosthetic valve (valve-in-valve procedure) - You had a prior bioprosthetic valve implantation - You have a pacemaker, defibrillator, or cardiac resynchronization device - You have been diagnosed with significant liver disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTtransthoracic echocardiography

Each study patient will undergo transthoracic echocardiography, transesophageal echocardiography, and cardiac magnetic resonance imaging following transcatheter aortic valve replacement.


Locations(1)

Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf

Düsseldorf, Germany

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NCT06896227


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