Aortic Valve Disease Clinical Trials

41 recruitingLast updated: June 18, 2026

There are 41 actively recruiting aortic valve disease clinical trials across 22 countries. Studies span Not Applicable, Phase 4. Top locations include Xi'an, Shaanxi, China, Plano, Texas, United States, Asheville, North Carolina, United States. Updated daily from ClinicalTrials.gov.


Aortic Valve Disease Trials at a Glance

41 actively recruiting trials for aortic valve disease are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 17 trials, with the heaviest enrollment activity in Xi'an, Plano, and Asheville. Lead sponsors running aortic valve disease studies include Closed Joint-Stock Company NeoCor, Nanjing First Hospital, Nanjing Medical University, and Second Affiliated Hospital, School of Medicine, Zhejiang University.

Browse aortic valve disease trials by phase

Treatments under study

About Aortic Valve Disease Clinical Trials

Looking for clinical trials for Aortic Valve Disease? There are currently 27 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Aortic Valve Disease trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Aortic Valve Disease clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 41 trials

Recruiting

Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study

Calcific Aortic StenosisChronic Coronary SyndromeAortic Stenosis+1 more
Azienda Ospedaliera "Sant'Andrea"250 enrolled5 locationsNCT07620925
Recruiting

Sapien 3 Transcatheter Aortic Valve Replacement in Young Aortic Valve Stenosis Patients From China

AORTIC VALVE DISEASESBicuspid Aortic Valve (BAV)
Xijing Hospital450 enrolled4 locationsNCT06830499
Recruiting
Not Applicable

CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

Aortic Valve DiseaseAortic StenosisAortic Valve Stenosis
EmStop Inc663 enrolled2 locationsNCT07276711
Recruiting
Not Applicable

J-Valve Transfemoral Pivotal Study

Aortic Valve RegurgitationAortic Valve Disease Mixed
JC Medical, Inc., an affiliate of Edwards Lifesciences LLC194 enrolled40 locationsNCT06455787
Recruiting

Aortopathy Relationship To Imagery and Kinocardiography Features (ARTIK)

Aortic Valve DiseaseAortic Aneurysm
Université Libre de Bruxelles180 enrolled1 locationNCT06286358
Recruiting

Prospective Long-Term Outcomes of a Standardized Ross Procedure

Aortic Valve Disease
Baylor Research Institute225 enrolled1 locationNCT06352671
Recruiting

Valved Graft PMCF Study

Aortic Valve DiseaseAortic DissectionAscending Aorta Abnormality
Abbott Medical Devices260 enrolled25 locationsNCT04754217
Recruiting
Not Applicable

Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation

Aortic Valve Disease
Nanjing First Hospital, Nanjing Medical University210 enrolled1 locationNCT04864145
Recruiting

Real World Data Collection on the INSPIRIS RESILIA Aortic Valve

Aortic Valve Disease
Edwards Lifesciences500 enrolled11 locationsNCT07120048
Recruiting
Not Applicable

The JenaValve ALIGN-AR LVAD Registry

Aortic Valve DiseaseLeft Ventricular DysfunctionAortic Valve Insufficiency+2 more
JenaValve Technology, Inc.50 enrolled15 locationsNCT06594705
Recruiting
Not Applicable

Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study

Aortic Valve DiseaseConduction Disturbances
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec80 enrolled1 locationNCT02153307
Recruiting

Expanded Studies on the SCAPIS Stockholm Reexamination Cohort

Heart FailureCoronary Artery DiseaseOral Microbiota+9 more
Danderyd Hospital1,400 enrolled1 locationNCT07476703
Recruiting

SAvvywire for Pacing and Procedural Hemodynamics In Transcatheter Aortic Valve Replacement Evaluation

Aortic Valve DiseaseTAVI(Transcatheter Aortic Valve Implantation)
dr Pim A.L. Tonino300 enrolled1 locationNCT07366671
Recruiting
Not Applicable

REpeat Intervention For Failed Surgical BioProsthEtic AorTic Valves (REPEAT)

Degenerative Aortic Valve Disease
Heart Center Leipzig - University Hospital890 enrolled1 locationNCT07462624
Recruiting
Phase 4

TRanscAtheter TreatMent of PurE Aortic Regurgitation With VitaFlow Liberty System

AORTIC VALVE DISEASESTranscatheter Aortic Valve Replacement (TAVR)aortic regurgitation
Ruijin Hospital120 enrolled4 locationsNCT06818084
Recruiting
Not Applicable

Comparative Research of Y-Incision vs. Standard Techniques for Aortic Root EnLargement

Severe Aortic Valve DiseaseAortic Valve Replacement (AVR)Small Aortic Annulus
willner nadav MD90 enrolled1 locationNCT07368322
Recruiting
Phase 4

Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement

ThromboembolismAORTIC VALVE DISEASES
Joon Bum Kim1,300 enrolled15 locationsNCT04258488
Recruiting

Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease

Aortic Valve DiseaseHeart Valve DiseaseTricuspid Valve Regurgitation+11 more
Second Affiliated Hospital, School of Medicine, Zhejiang University10,000 enrolled15 locationsNCT07267117
Recruiting

Outcomes in Moderate Mixed Aortic Valve Disease

Mixed Aortic Valve Disease
Leiden University Medical Center1,900 enrolled1 locationNCT06789211
Recruiting
Not Applicable

CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation

Aortic Valve DiseaseAortic Valve Stenosis
University of Colorado, Denver200 enrolled1 locationNCT07008911