FITting Non-invasive Tests in Lynch Syndrome Surveillance

This study is investigating whether stool-based tests (specifically the FIT test — a fecal immunochemical test) can serve as a useful screening tool in between colonoscopy appointments for people with Lynch syndrome, a genetic condition that significantly increases the risk of colorectal cancer. Lynch syndrome requires regular colonoscopy surveillance, but researchers want to know if adding a simple stool test can help catch cancers or precancerous changes earlier, between those scheduled scopes. **You may be eligible if...** - You have a confirmed diagnosis of Lynch syndrome with a pathogenic (disease-causing) variant in the MLH1, MSH2, MSH6, PMS2, or EPCAM genes - You are between 20–75 years old (MLH1, MSH2, EPCAM carriers) or 30–75 years old (PMS2 or MSH6 carriers) - You have an upcoming standard colonoscopy as part of your routine Lynch syndrome surveillance - You are willing to collect stool samples and complete surveys **You may NOT be eligible if...** - You have not yet had genetic testing confirming Lynch syndrome - You have previously had a partial or total bowel removal (colectomy) - You have inflammatory bowel disease or an active cancer - You are pregnant - You are a newly diagnosed Lynch syndrome patient below the minimum age thresholds Talk to your doctor to see if this trial is right for you.