SPYRAL GEMINI Pilot Study

This study is testing a procedure called renal denervation — where nerves around the kidney and liver arteries are disrupted using a catheter — to lower blood pressure in people whose high blood pressure is not controlled with medications. **You may be eligible if...** - You are between 18 and 80 years old - You have high blood pressure with a systolic reading (top number) of 150–179 mmHg in the office - Your 24-hour average blood pressure monitoring also shows elevated readings **You may NOT be eligible if...** - Your blood vessels are not suitable for the procedure - You have had a prior stroke or TIA (mini-stroke) - You have type 1 diabetes or use insulin or certain diabetes medications - Your high blood pressure has a known secondary cause - Your kidney function is significantly impaired - You are pregnant, nursing, or planning to become pregnant Talk to your doctor to see if this trial is right for you.