RecruitingNCT06924463

Identification of Specific Molecular Signatures in Pediatric, Adolescent, and Young Adult Rhabdomyosarcoma Through Spatial Proteome Analysis Using Mass Spectrometry

Identification de Signatures moléculaires spécifiques Dans le Rhabdomyosarcome de l'Enfant, de l'Adolescent et du Jeune Adulte, Par Analyse Spatiale du protéome Par spectrométrie de Masse


Sponsor

Lille University

Enrollment

20 participants

Start Date

Mar 13, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This non-interventional study aims to develop spatial proteomics for analyzing small FFPE tumor samples in rhabdomyosarcoma. It will identify molecular signatures linked to tumor regions, subtypes, survival, and treatment resistance, using pre-existing samples and data.


Eligibility

Min Age: 0 YearsMax Age: 25 Years

Plain Language Summary

Simplified for easier understanding

This is a research study analysing stored tumour tissue samples (from past biopsies or surgeries) from children and young adults who were diagnosed with rhabdomyosarcoma (a cancer of muscle-like tissue) to look for specific molecular patterns that might predict outcomes or guide future treatment. **You may be eligible if...** - You were diagnosed with rhabdomyosarcoma at any point between age 0 and 25 - Your diagnosis was confirmed by pathology - You were treated at the Oscar Lambret Center (France) between January 2005 and November 2024 - You (or your guardian) have not objected to the reuse of your tissue samples or data for research **You may NOT be eligible if...** - No tumour tissue sample (preserved in FFPE block) is available from your original biopsy or surgery - You are currently under legal guardianship or trusteeship and consent cannot be obtained Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNone AHT

This study does not involve any interventions. It analyzes pre-existing biological samples (FFPE tumor tissue) and clinical data from patients with rhabdomyosarcoma.


Locations(1)

Oscar Lambret Center

Lille, Nord, France

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NCT06924463


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