RecruitingNot ApplicableNCT06796543

Targeted Oligometastatic Radiation in Pediatric and Young Adult Patients With Soft Tissue and Bone Sarcoma

Sponsor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Enrollment

70 participants

Start Date

Mar 25, 2025

Study Type

INTERVENTIONAL

Conditions

Metastatic Sarcoma Ewing Sarcoma Rhabdomyosarcoma Radiation Therapy Patient

Summary

This study is designed for children, adolescents and young adults undergoing radiation therapy for metastatic sarcoma. The aim of the study is to investigate if the investigators can improve the overall survival of these patients by targeting metastatic sites with radiation.

Eligibility

Max Age: 39 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether delivering targeted radiation to a small number of metastatic spots (oligometastases — when cancer has spread to only a few areas) can help control disease in young patients (under 39) with bone or soft tissue sarcoma. The goal is to delay or reduce the need for more intensive systemic treatments. **You may be eligible if...** - You are under 39 years old (newly diagnosed with metastatic sarcoma) OR any age (with sarcoma that progressed after treatment) - You have been diagnosed with soft tissue or bone sarcoma with a limited number of metastatic spots - You are able to perform daily activities without major limitation (Karnofsky/ECOG score meeting criteria) - Your metastatic lesions are measurable on imaging **You may NOT be eligible if...** - You have too many metastatic sites to be considered oligometastatic - You are not well enough to undergo radiation treatment - Your cancer has spread extensively beyond what qualifies as oligometastatic Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONConsolidative radiation therapy (cRT)

Treatment that is given after cancer has disappeared following the initial therapy. Consolidation therapy is used to kill any cancer cells that may be left in the body. It may include radiation therapy, a stem cell transplant, or treatment with drugs that kill cancer cells. Also called intensification therapy and postremission therapy.