The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial
The Gut Microbiome Center (Centar za crijevni mikrobiom)
40 participants
Nov 1, 2024
INTERVENTIONAL
Conditions
Summary
ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to determine whether probiotic treatment can significantly modulate gut microbiome composition and functionality in endometriosis patients, specifically parameters associated with the estrobolome.
Eligibility
Inclusion Criteria2
- Minimum Age: - Maximum Age: 35 Years Sex: Female Gender Based: Ye - only women can participate in this study Accepts Healthy Volunteers: No
- adult subjects with stage III or IV endometriosis diagnosis confirmed by biopsy
Exclusion Criteria7
- Age > 35 years
- Immunocompromised patients
- Patients with chronic inflammatory diseases (e.g., autoimmune disorders)
- Pregnancy
- Use of supplements and foods with probiotics
- Use of immunosuppressant, antibiotic, proton pump inhibitors and corticosteroid drugs
- Use of probiotics product less than one month before start of study or during study
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Interventions
Multistrain probiotic formulation (Omni Biotic Stress), 1 sachet daily for 8 weeks
Inert powder identical in appearance and taste to probiotic, 1 sachet daily for 8 weeks
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06929364