HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
Optimizing Open Placebos for Chronic Pain Patients
Rhode Island Hospital
340 participants
Mar 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. This study will include patients with chronic low back pain. The main question it aims to answer is: How do rationales influence the effects of open-label placebos? Researchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Open-label placebo pill for 21 days at 2 per day
Scientific rationale about the placebo effect
Mindfulness based rationale
Basic epidemiological information about chronic pain to achieve structural equivalence for the control groups
Locations(1)
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NCT06931158