RecruitingNot ApplicableNCT06931158

HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain

Optimizing Open Placebos for Chronic Pain Patients


Sponsor

Rhode Island Hospital

Enrollment

340 participants

Start Date

Mar 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. This study will include patients with chronic low back pain. The main question it aims to answer is: How do rationales influence the effects of open-label placebos? Researchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.


Eligibility

Min Age: 18 YearsMax Age: 89 Years

Inclusion Criteria5

  • chronic pain (pain lasting at least 3 months, pain intensity 4/10 or over and interference 3/10 or over)
  • at least 18 years old
  • English speaking
  • have a smartphone or computer with video access
  • the chronic pain is concentrated into the patient's lower back (tentative criteria based on recruitment rate)

Exclusion Criteria4

  • Have chronic pain because of a cancer diagnosis
  • Over 89 years of age
  • Suspect an allergy to any placebo ingredient
  • Currently receiving worker's compensation.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGOpen-label Placebo

Open-label placebo pill for 21 days at 2 per day

BEHAVIORALStandard Rationale

Scientific rationale about the placebo effect

BEHAVIORALMindfulness

Mindfulness based rationale

BEHAVIORALControl Rationale

Basic epidemiological information about chronic pain to achieve structural equivalence for the control groups


Locations(1)

Rhode Island Hospital

Providence, Rhode Island, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06931158


Related Trials