RecruitingNot ApplicableNCT06931158

HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain

Optimizing Open Placebos for Chronic Pain Patients


Sponsor

Rhode Island Hospital

Enrollment

340 participants

Start Date

Mar 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. This study will include patients with chronic low back pain. The main question it aims to answer is: How do rationales influence the effects of open-label placebos? Researchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.


Eligibility

Min Age: 18 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Control Rationale, a behavioral approach called Mindfulness, and others for people with chronic low-back pain and chronic pain. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOpen-label Placebo

Open-label placebo pill for 21 days at 2 per day

BEHAVIORALStandard Rationale

Scientific rationale about the placebo effect

BEHAVIORALMindfulness

Mindfulness based rationale

BEHAVIORALControl Rationale

Basic epidemiological information about chronic pain to achieve structural equivalence for the control groups


Locations(1)

Rhode Island Hospital

Providence, Rhode Island, United States

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NCT06931158


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