RecruitingNot ApplicableNCT06933199

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis - Prospective Trial NeoSTROBE

Sponsor

University Hospital Ostrava

Enrollment

260 participants

Start Date

May 1, 2025

Study Type

INTERVENTIONAL

Conditions

Brain Metastases

Summary

This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases (BM) in the frame of the Czech neurooncology network. Most relevant studies published to date used single-fraction radiotherapy and dealt with the inherent bias related to their retrospective nature. The researchers aim to increase the level of evidence for this treatment paradigm together with other similar ongoing studies.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying a technique called neoadjuvant stereotactic radiosurgery — high-precision targeted radiation given before brain surgery — for patients with cancer that has spread to the brain (brain metastases). The goal is to see if treating tumors with radiation first makes surgery safer and more effective. **You may be eligible if...** - You have cancer that has spread to the brain (brain metastases) - Your brain metastases are large enough that surgery is being considered - You are an adult in good enough health for both radiation and surgery - Your overall cancer is being managed and you have a reasonable life expectancy **You may NOT be eligible if...** - You have more than a certain number of brain metastases - Your tumors are too small to require surgery - You have had prior radiation to the brain in the same area - You have serious bleeding disorders or active brain infections - You cannot receive anesthesia safely Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONNeoadjuvant Stereotactic Radiotherapy (NaSRT)

Neoadjuvant Stereotactic Radiotherapy (NaSRT) gives radiotherapy before surgery from many different angles around the body. The beams meet at the tumor. This means the tumor receives a high dose of radiation and the tissues around it receive a much lower dose. This lowers the risk of side effects.

RADIATIONPostoperative Stereotactic Radiotherapy (SRT)

Postoperative Stereotactic Radiotherapy (SRT) gives radiotherapy after surgery from many different angles around the body. The beams meet at the tumor. This means the tumor receives a high dose of radiation and the tissues around it receive a much lower dose. This lowers the risk of side effects.