RecruitingNot ApplicableNCT06936397

Cognitive Remediation Therapy for Schizophrenia: Effects on EEG and Emotional Regulation

A Randomized Controlled EEG-GSR Study on the Effects of Cognitive Remediation Therapy on Neurophysiological and Emotional Regulation Markers in Schizophrenia


Sponsor

Beykoz University

Enrollment

60 participants

Start Date

Mar 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to determine whether Cognitive Remediation Therapy (CRT) can improve attention, memory, and emotional regulation in people with schizophrenia. CRT is a structured program that includes exercises to strengthen cognitive skills such as problem-solving, working memory, and emotion regulation. The study will recruit 60 participants: 30 individuals with schizophrenia and 30 healthy individuals of similar age and gender. Those with schizophrenia will be randomly assigned to either receive CRT or be placed on a waitlist without therapy. All participants will undergo non-invasive brain activity (EEG) and emotional response (GSR) recordings before and after the therapy. The study's main question is: Does participating in a 12-week CRT program improve brain-based markers of attention and emotional regulation in people with schizophrenia? Additional tests, such as memory and emotion recognition tasks and self-report questionnaires, will help assess changes in thinking skills and emotional well-being. The study may help better understand how CRT affects both brain function and quality of life in schizophrenia.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria11

  • Diagnosed with schizophrenia according to DSM-5 criteria
  • Age between 18 and 55 years
  • Clinically stable (no hospitalization or medication change within 1 month)
  • Minimum primary school education
  • Able to provide informed consent
  • Right-handed (for EEG protocol consistency)
  • No history of psychiatric or neurological disorders
  • Age- and gender-matched to schizophrenia group
  • No current medication affecting CNS
  • Able to provide informed consent
  • Right-handed

Exclusion Criteria6

  • Current or past substance use disorder (within the past year)
  • Comorbid neurological illness (e.g., epilepsy, traumatic brain injury)
  • Current use of benzodiazepines or medications that significantly affect cognitive function
  • Intellectual disability or MoCA score \< 20
  • Visual or hearing impairments that could interfere with task performance
  • Participation in a psychological intervention in the last 3 months

Interventions

BEHAVIORALCognitive Remediation Therapy

CRT is a structured behavioral intervention consisting of weekly 60-minute sessions for 12 weeks. The therapy includes tasks to enhance cognitive skills such as attention, memory, executive function, and emotional regulation using computer-based training and therapist-guided exercises.


Locations(1)

Beykoz University

Istanbul, Turkey (Türkiye)

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