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RecruitingNCT06938516

Prospective Observational Study On The Impact Of Nebilet In Blood Pressure Control In Hypertensive Patients (HYIMPACT)

IMPACT of Nebilet in Blood Pressure Control in Patients With HYpertension: An Observational, Longitudinal Study

Sponsor

A.Menarini Asia-Pacific Holdings Pte Ltd

Enrollment

4,537 participants

Start Date

Dec 20, 2023

Study Type

OBSERVATIONAL

Conditions

Hypertension

Summary

The HYIMPACT study (IMPACT of Nebilet® in Blood Pressure Control in Patients with Hypertension) is a multinational, multicenter, observational, prospective, longitudinal real-world evidence study designed to assess the effectiveness and safety of Nebilet® (nebivolol) in hypertensive patients. The study aims to evaluate changes in systolic and diastolic blood pressure from baseline to 12, 24, and 36 months, as well as treatment adherence, quality of life, prescription patterns, and cardiovascular outcomes. A total of approximately 5,000 hypertensive patients with or without cardiovascular comorbidities will be enrolled across seven Asian countries (Malaysia, Indonesia, the Philippines, Korea, Vietnam, Thailand, and Taiwan). Patients newly initiated on Nebilet®-based treatment or already receiving Nebilet® for no more than two weeks prior to screening will be eligible for inclusion. Patients will be followed at regular intervals for up to three years. The study will also assess the correlation between home and office blood pressure measurements and compare Nebilet® monotherapy with combination therapy in achieving target blood pressure control. The findings from this study will provide real-world insights into the clinical management of hypertension with Nebilet® and its impact on patient outcomes.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This is an observational study tracking how well a blood pressure medication called nebivolol (brand name Nebilet) controls blood pressure in patients with hypertension in real-world clinical practice. No new medications are being tested — researchers are simply collecting data on how patients do over time. **You may be eligible if...** - You are 18 or older with newly diagnosed or uncontrolled high blood pressure - Your doctor has recently prescribed nebivolol or you have been taking it for 2 weeks or less - You are willing to participate and sign a consent form **You may NOT be eligible if...** - You had a recent cardiovascular event (heart attack, stroke) within the last 3 months - You have severe heart failure (NYHA Class IV — unable to carry out any physical activity) - You have a medical reason you cannot take nebivolol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(49)

Telogorejo Hospital

Semarang, Central Java, Indonesia

Bethesda Hospital

Yogyakarta, Central Java, Indonesia

Panti rapih Hospital

Yogyakarta, Central Java, Indonesia

Husada Utama Hospital

Surabaya, East Java, Indonesia

Premere Surabaya Hospital

Surabaya, East Java, Indonesia

National Cardiovascular Center Harapan Kita Hospital

Jakarta, Jakarta Special Capital Region, Indonesia

Metropolitan Medical Centre Hospital

Jakarta, Jakarta Special Capital Region, Indonesia

Bidakara Medical Centre

Selatan, Jakarta Special Capital Region, Indonesia

PT Ekamas International Hospital

Pekanbaru, Riau, Indonesia

Stella Maris Hospital

Makassar, South Sulawasi, Indonesia

Bukit Asam Medika Hospital

Palembang, South Sumatra, Indonesia

Advent Hospital

Bandung, West Java, Indonesia

Borromeus Hospital

Bandung, West Java, Indonesia

RSUD Syamsudin Hospital

Sukabumi, West Java, Indonesia

Semen Padang Hospital

Padang, West Sumatra, Indonesia

DrThong,Leow,Chiam & Partners

Kuala Lumpur, Kuala Lumpur, Malaysia

Klinik Pembangunan Sdn. Bhd

Kuala Lumpur, Kuala Lumpur, Malaysia

Pantai HKL

Kuala Lumpur, Kuala Lumpur, Malaysia

Columbia Asia Hospital Seremban

Seremban, Negeri Sembilan, Malaysia

Mawar Medical Centre

Seremban, Negeri Sembilan, Malaysia

Bukit Tinggi Medical Centre

Klang, Selangor, Malaysia

Mary Mediatrix Medical Center

Lipa, Batangas, Philippines

Veterans Memorial Medical Center

Quezon City, Manila, Philippines

Kangbuk Samsung Hospital

Seoul, Jongno District Seoul, South Korea

Eunpyeong St. Mary's Hospital

Seoul, Seoul, South Korea

Chonnam National University Hospital

Gwangju, South Korea

Far Eastern Memorial Hospital (FEMH)

New Taipei City, Banqiao, Taiwan

Changhua Christian Hospital (CCH)

Changhua, Changhua County, Taiwan

Chang Gung Memorial Hospital-Chiayi branch (CGMH-CY)

Pozi, Chiayi County, Taiwan

Chung Gung Memorial Hospital-Linkou Branch (CGMH-LK)

Taoyuan, Guishan District, Taiwan

Hualien Tzu-Chi Hospital (HTCH)

Hualien City, Hualien County, Taiwan

Asia University Hospital (AUH)

Taipei, Nangang Dist., Taiwan

National Cheng Kung University Hospital (NCKUH)

Tainan, North District, Taiwan

Kaohsiung Medical University Hospital (KMUH)

Kaohsiung City, Sanmin District, Taiwan

Taipei Medical University Hospital (TMUH)

Taipei, Xinyi District, Taiwan

Taichung Veterans General Hospital (TVGH)

Taichung, Xitun District, Taiwan

Chi-Mei Medical Center (CMC)

Tainan, Yongkang Dist., Taiwan

MacKay Memorial Hospital (MMH)

Taipei, Zhongshan District, Taiwan

National Taiwan University Hospital (NTUH)

Taipei, Zhongzheng District, Taiwan

Vajira Hospital Namindradhiraj University

Dusit, Bangkok, Thailand

Wetchakarunrasm Hospital

Nong Chok, Bangkok, Thailand

Burapha University

Chon Buri, Changwat Chon Buri, Thailand

Anand Mahidhol Hospital

Lopburi, Changwat Lop Buri, Thailand

Central Chet Institute

Nonthaburi, Changwat Nonthaburi, Thailand

Chiang Mai University

Chiang Mai, Chiang Mai, Thailand

CanTho General Hospital

Can Tho, Can Tho City, Vietnam

Hanoi Heart Hospital

Hanoi, Hanoi, Vietnam

Cho Ray Hospital

Ho Chi Minh City, Ho Chi Minh, Vietnam

Hue Central Hospital

Huế, Hue, Vietnam

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NCT06938516

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