RecruitingNot ApplicableNCT06941298

Neural and Psychiatric Consequences of Cannabis Use in Adolescents

Sponsor

University of Miami

Enrollment

280 participants

Start Date

Mar 4, 2025

Study Type

INTERVENTIONAL

Conditions

Depression Cannabis Use

Summary

The goal of this study is to investigate the effects of cannabis on brain function among adolescents with depression.

Eligibility

Min Age: 14 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This research study is examining how regular cannabis use affects the brain and mental health of teenagers and young adults, particularly looking at the relationship between cannabis and depression. **You may be eligible if...** - You are an adolescent or young adult (aged 14–20) - You use cannabis frequently (at least 15 out of the past 30 days, confirmed by a urine test), OR you have symptoms of depression (even if mild or moderate) **You may NOT be eligible if...** - You have metal implants, braces, or claustrophobia that prevent you from having an MRI - You are pregnant - You have a diagnosed neurological condition (like multiple sclerosis) or a significant medical illness - You have a substance use disorder for drugs other than cannabis - Your IQ is estimated below 80 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALNeuroimaging Investigation

Participants will undergo fMRI neuroimaging at two timepoints, at the start of the study and at the 1 year follow up. The fMRI is one hour in duration. During the fMRI, participants will complete two tasks investigating diverse aspects of reward circuitry activity. After this is completed, participants will be followed up for another year clinically.