A Phase I Study of QLS12010 Capsules: Safety, Tolerability, PK, PD, and Food Effects in Healthy Adults and Moderate to Severe Atopic Dermatitis Patients

This study is testing a new experimental drug called QLS12010 in healthy adults and in people with moderate-to-severe atopic dermatitis (eczema) to see how safe it is, how the body processes it, and whether food affects how it is absorbed. **You may be eligible if...** - You are between 18 and 45 years old (healthy volunteer part) or 18–75 (eczema part) - For the eczema part: you have had chronic atopic dermatitis for at least 6 months - For the eczema part: your eczema is moderate-to-severe (covering at least 10% of your body, with significant rash scores) - You have significant itch (itch score of 4 or higher on average) - Your weight meets the minimum requirement (50 kg for men, 45 kg for women) **You may NOT be eligible if...** - Your eczema has been well-controlled with current treatments - You have significant heart, liver, kidney, or immune system problems - You are pregnant or breastfeeding - You have recently used certain other eczema medications Talk to your doctor to see if this trial is right for you.