RecruitingNCT06951100

Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation


Sponsor

University of Edinburgh

Enrollment

300 participants

Start Date

May 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Age 18 years and over
  • Primary presentation with symptoms related to atrial fibrillation
  • Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram
  • Able to provide informed consent

Exclusion Criteria6

  • Previous myocardial infarction
  • Previous coronary revascularisation procedure
  • Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media
  • Pregnancy or breast feeding
  • Deemed unsuitable for participation in the study by the attending clinician
  • Previous enrolment in the trial

Interventions

DIAGNOSTIC_TESTCT coronary angiography

To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)


Locations(1)

Royal Infirmary of Edinburgh

Edinburgh, East of England, United Kingdom

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NCT06951100


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