RecruitingNCT06951100

Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation

Sponsor

University of Edinburgh

Enrollment

300 participants

Start Date

May 1, 2025

Study Type

OBSERVATIONAL

Conditions

Atrial Fibrillation (AF)

Summary

The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how having a fast heart rate caused by atrial fibrillation (AF) — a common irregular heartbeat — can injure or stress the heart muscle. By using imaging and blood tests, researchers aim to better understand the mechanisms of heart injury in people presenting with rapid AF, which could lead to improved treatment approaches. **You may be eligible if...** - You are 18 years or older - You are presenting to hospital with symptoms caused by atrial fibrillation (such as palpitations, breathlessness, or dizziness) - Your heart rate is above 100 beats per minute due to AF, confirmed on an ECG - You are able to provide informed consent **You may NOT be eligible if...** - You have had a previous heart attack - You have previously had a heart bypass or stent procedure - You have significant kidney disease (eGFR below 30) or a serious allergy to contrast dye - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTCT coronary angiography

To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)

Locations(1)

Royal Infirmary of Edinburgh

Edinburgh, East of England, United Kingdom

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NCT06951100

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