RecruitingNot ApplicableNCT06951386

The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome

The Impact of 12 Weeks Intervention With Plant-based Oat Drink Rich in Short-chain Fatty Acids on Postprandial Lipidemia in Individuals at Risk for Metabolic Syndrome

Sponsor

KU Leuven

Enrollment

50 participants

Start Date

Feb 11, 2025

Study Type

INTERVENTIONAL

Conditions

Body Composition Metabolic Syndrome Blood Pressure Anthropometry Metabolomics Energy Expenditure Glycemia Lipaemia

Summary

During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria8

male and female participants
central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men)
One additional risk factor for metabolic syndrome:
Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl)
Triglyceride concentration ≥ 150 mg/dl
HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men
Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg
knowledge of English

Exclusion Criteria10

gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea
history of abdominal surgery, except for appendectomy
Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids
Use of antibiotics 3 months prior to the start or during the study
Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study
Being on weight loss, gluten-free, lactose-free or vegan diet
Pregnancy, lactation or wish to become pregnant
Previous or current substance/ alcohol dependence or abuse
Hyper- or hypothyroidism
Allergy or intolerance to oat milk

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