RecruitingPhase 4NCT06951802
Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine
Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine A Single-Centre, Prospective, Randomized, Controlled Trial
Sponsor
Insel Gruppe AG, University Hospital Bern
Enrollment
118 participants
Start Date
Dec 3, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
RCT comparing intraoperative administration of low-dose ketamine during laparoscopic endometriosis operation and the postoperative pain outcome
Eligibility
Sex: FEMALEMin Age: 18 Years
Inclusion Criteria5
- Patients undergoing surgery for endometriosis operation requiring general anaesthesia at the Inselspital, Bern University Hospital, University of Bern, Department of gynaecology and obstetrics.
- Age ≥ 18 years
- American Society of Anesthesiologist (ASA) physical status 1-3
- Patients with known or suspected endometriosis
- Written informed consent.
Exclusion Criteria13
- Age < 18 years
- ASA physical status ≥4
- Higher-grade atrioventricular block without pacemaker
- Severe hypovolemia or bradycardia
- Uncontrolled hyper- or hypotension
- Liver disease
- Known malignant hyperthermia
- Cardiovascular instability or severe heart failure (New York Heart Association classification (NYHA) > III)
- Myocardial infarction during the last 30 days prior to surgery
- Increased intracranial or increased intraocular pressure
- Limited peripheral autonomic activity, hypersensitivity to ketamine or propofol or its components
- Pregnancy
- Rejection or lack of consent of the patient or relatives
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Interventions
DRUGKetamine
Low-dose administration of ketamine during laparoscopic surgery
DRUGPropofol
Control group
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06951802
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