RecruitingNCT06956560

Platelet Derived Growth Factor Receptor ß (PDGFRß) Imaging in Cardiac Fibrosis

Microdosing, Non-randomized, Clinical Trial to Investigate Binding of Positron Emission Tomography Tracer [68ga]Ga-DOTA-Cys-ATH001 Targeting Platelet-derived Growth Factor Receptor Beta (PDGFRß) in Healthy Subject as Compared to Patients With Cardiac Fibrosis.

Sponsor

Uppsala University

Enrollment

30 participants

Start Date

Jun 1, 2025

Study Type

OBSERVATIONAL

Conditions

ST-elevation Myocardial Infarction (STEMI)Heart Failure With Preserved Ejection Fraction (HFpEF)

Summary

An observational, cross-sectional, longitudinal, microdosing Position Emission Tomography (PET) imaging study to investigate platelet derived growth factor receptor beta (PDGFRß) expression in the heart of patients with high or low risk of heart failure after a ST-Elevation Myocardial Infarction (STEMI) after a percutaneous coronary intervention (PCI) with a stent procedure, as well as in patients with heart failure with preserved ejection fraction (HFpEF) and healthy individuals.

Eligibility

Min Age: 40 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new imaging technique to detect and measure scarring (fibrosis) in the heart. Researchers use a special tracer that targets a protein linked to heart scarring, giving doctors a more precise picture of heart damage. The goal is to see how well this scan works in people with and without known heart conditions. **You may be eligible if...** - You are between 40 and 70 years old - You have been diagnosed with a condition that causes heart scarring (such as certain cardiomyopathies) OR you are a healthy volunteer without heart disease - You are willing and able to give informed consent and follow the study procedures - Women of childbearing age are using effective contraception **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have significant kidney disease or other conditions that could interfere with the scan - You have had a recent heart attack or other unstable heart condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONPET/MRI or separate PET/CT and MRI

PET/MRI or separate PET/CT and MRI using the following imaging protocol: 15O-H20 (myocardial perfusion, up to 10 min dynamic PET scan), \[68Ga\]Ga-DOTA-Cys-ATH001 (PDGFRß PET, up to 60 min dynamic + static full body PET scans), and Gd-MRI (extracellular volume in infarct, around 10 min MRI scan). Cohort 1 and 2 are examined twice, first one week after PCI/stent and then a second examination 2 to 8 months after the first. Cohorts 3, and 4 are examined once.