Outcomes Following Limb Sparing Surgery for Soft Tissue Sarcoma
Body Image, Health-related Quality of Life, and Function After Soft Tissue Sarcoma Resection
Amsterdam UMC
150 participants
Apr 24, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this study is to assess body image, health-related quality of life (QoL), and functioning (gait function, joint function, and walking ability) in patients after resection of localized soft tissue sarcoma (STS) of the extremities. A secondary objective is to assess the influence of different variables (e.g., radiotherapy, ethnicity, etc.) on body image, health-related QoL, and functioning. Patients who underwent a surgical resection at the Amsterdam UMC between 2010 and 2021 will be approached to participate in the study. Participants will complete four questionnaires and undergo a physical examination. Additionally, they will have a 3D gait analysis, a 6-minute walk test with gas analysis, and a muscle strength assessment. Furthermore, muscle volume change will be evaluated on pre- versus postoperative MRI scans.
Eligibility
Inclusion Criteria3
- Treated with surgical resection for primary non-metastatic extremity STS at the Amsterdam UMC between 2010-2021.
- Being able to visit the Amsterdam UMC, location AMC once or twice.
- Pregnant patients must agree to be scheduled 5 months after their pregnancy ends.
Exclusion Criteria1
- Patients who cannot maintain 6 minutes of walking will be excluded from the 6-minute walk test.
Interventions
The surgical resection of STS serves as the primary treatment, aiming to completely remove the tumor with a wide margin of surrounding healthy tissue to minimize the risk of recurrence. Radiotherapy and/or chemotherapy may be incorporated depending on the tumor's type, stage, and grade.
Locations(1)
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NCT06962072