Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty
Effectiveness of Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Patients Undergoing Open Rhinoplasty: A Randomized Controlled Trial
Ain Shams University
50 participants
May 12, 2025
INTERVENTIONAL
Conditions
Summary
The study aims to evaluate the effectiveness of intraoperative combination of ketamine and magnesium sulfate infusions on postoperative analgesia in patients undergoing open rhinoplasty.
Eligibility
Inclusion Criteria4
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I - II.
- Scheduled for rhinoplasty under general anesthesia.
Exclusion Criteria6
- Receiving analgesic or any medications since 48 hours before the surgery.
- Drug addiction.
- Cardiovascular disease.
- Respiratory disease, renal, liver, metabolic and neurological disease.
- Pregnancy or breast feeding.
- Asthma.
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Interventions
Patients will receive a bolus of 0.5 mg/kg of ketamine given over a period of ten minutes followed by a constant infusion of 0.25 mg/kg/hr and a bolus dose of 30 mg/kg of magnesium sulfate during a 10-minute period followed by a continuous infusion of 9 mg/kg/hr.
Patients will receive saline 0.9% as a control group.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06966518