Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring
Randomized and Placebo Controlled Study to Evaluate the Effect of Magnesium Sulfate on Intraoperative Neuromonitoring.
Loma Linda University
50 participants
Mar 18, 2022
INTERVENTIONAL
Conditions
Summary
Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied. This is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.
Eligibility
Inclusion Criteria3
- Patients aged 18 to 80 years
- Belonging to American Society of Anesthesiologists physical status (ASA) I, II
- Undergoing elective spine or cranial surgery where intraoperative neuromonitoring including short latency somatosensory evoked potentials (SSEP or SEP) and transcranial electrical muscle motor evoked potentials recording from muscles (TceMEP or TcMEP or mMEP or MEP) is planned.
Exclusion Criteria8
- Magnesium use within the last 2 days, either intravenous or oral supplements.
- Patients with known electrolyte imbalances (Sodium \<135 or \>145 mmol/L OR Potassium \< 3.5 or \> 5.0 mmol/L, Magnesium \>1.2 mmol/L.
- Severe cardiac or cardiac conduction disorders.
- Severe pulmonary disease.
- Patients with significant neuromuscular disorders or preexisting motor or sensory deficits other than focal upper limb neuropathy or focal cervical radiculopathy or mild cervical myelopathy.
- Severe Renal disease - serum creatinine of \> 2 mg/dl.
- Pregnant or breastfeeding patients.
- Unable to obtain adequate baseline SSEPs and MEPs.
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Interventions
Effect of 40mg/kg Magnesium sulfate bolus dosed to ideal body weight on intraoperative neuromonitoring
20 ml of normal saline bolus will be administered to the control group over 10 mins.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04938765