Chimeric Antigen Receptor Natural Killer Cell Therapy for High-risk Lymphoma Patients With Primary Sjogren's Syndrome

This study is testing CAR-NK cell therapy — a cutting-edge treatment that uses genetically engineered immune cells (natural killer cells) — for people with primary Sjogren's syndrome who have developed high-risk lymphoma (a type of blood cancer). **You may be eligible if...** - You are between 18 and 70 years old - You have a confirmed diagnosis of primary Sjogren's syndrome (a chronic autoimmune condition affecting moisture-producing glands) - You have persistent enlarged salivary glands, lymph nodes, liver, or spleen — and at least two of: cryoglobulinemia, low C4 levels, low white blood cell count, or positive anti-SSA/SSB antibodies - Your liver and kidney function meets the required thresholds **You may NOT be eligible if...** - You have significant other autoimmune conditions beyond primary Sjogren's - You have active uncontrolled infections - You have serious organ dysfunction Talk to your doctor to see if this trial is right for you.