OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa

This study is investigating how to optimize malaria treatment in African children and adolescents living with HIV who are on dolutegravir-based HIV therapy — to ensure both diseases are treated effectively without the treatments interfering with each other. **You may be eligible if...** - You are a child or adolescent living with HIV and are currently on a dolutegravir-based HIV regimen for at least 14 days - You have tested negative for malaria at enrollment - You live within approximately 30 km of the study clinic - You and/or your guardian have given consent to participate and attend all follow-up visits - OR: You are an HIV-uninfected child with documented negative HIV status **You may NOT be eligible if...** - You have significant other illnesses such as active tuberculosis, cancer, hepatitis B/C, diabetes, or severe malnutrition - You cannot commit to follow-up visits Talk to your doctor to see if this trial is right for you.