RecruitingNot ApplicableNCT06968312

Hexadecanal as an Addon to Cognitive Processing Therapy for PTSD

Testing Potential Enhancement of Standard Cognitive Processing Therapy for PTSD Using Hexadecanal: A Randomized Controlled Trial


Sponsor

Tel Aviv University

Enrollment

40 participants

Start Date

May 5, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This RCT investigates whether Cognitive Processing Therapy, a first line treatment for PTSD, can be enhanced by the use of the odor molecule Hexadecenal (HEX). HEX is secreted from body odor and has been shown to promotes psychological well-being and positive social interaction. For the active group Hex will be diffused in the treatment room during all treatment sessions. For the control group a vehicle placebo molecule will be diffused. Both therapists and patients will be blind to study condition.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether exposure to a naturally occurring odor molecule called hexadecanal — which humans produce themselves — can boost the effectiveness of a trauma-focused therapy called Cognitive Processing Therapy (CPT) for people with PTSD. **You may be eligible if...** - You are 18 or older with a diagnosis of PTSD according to standard criteria - You are eligible to receive CPT therapy at the National Center for Traumatic Stress and Resilience - You do not have any known allergies to the scent compound **You may NOT be eligible if...** - You have bipolar disorder, psychosis, or a neurological condition - You have an active drug addiction - You are currently receiving another form of psychotherapy - You were born without the ability to smell (congenital anosmia) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCognitive Processing Therapy + Hexadecanal

Cognitive Processing Therapy is a protocolized, trauma-focused, CBT type treatment for PTSD.

OTHERHexadecanal - Molecule Distribution in the Therapy room

Distribution of a naturally secreted molecule from body odor (Hexadecanal).


Locations(1)

Tel Aviv University

Tel Aviv, Israel

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NCT06968312


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