Hexadecanal as an Addon to Cognitive Processing Therapy for PTSD
Testing Potential Enhancement of Standard Cognitive Processing Therapy for PTSD Using Hexadecanal: A Randomized Controlled Trial
Tel Aviv University
40 participants
May 5, 2025
INTERVENTIONAL
Conditions
Summary
This RCT investigates whether Cognitive Processing Therapy, a first line treatment for PTSD, can be enhanced by the use of the odor molecule Hexadecenal (HEX). HEX is secreted from body odor and has been shown to promotes psychological well-being and positive social interaction. For the active group Hex will be diffused in the treatment room during all treatment sessions. For the control group a vehicle placebo molecule will be diffused. Both therapists and patients will be blind to study condition.
Eligibility
Inclusion Criteria3
- Diagnosis of PTSD according to DSM-5
- Age 18 years and over
- Eligible for CPT treatment at the National Center for Traumatic Stress and Resilience
Exclusion Criteria4
- Bipolar disorder, psychosis, neurological disorders
- Drug Addiction
- Parallel psychotherapy
- Congenital or acquired anosmia.
Interventions
Cognitive Processing Therapy is a protocolized, trauma-focused, CBT type treatment for PTSD.
Distribution of a naturally secreted molecule from body odor (Hexadecanal).
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06968312