Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

This study is testing a sublingual (under-the-tongue) formulation of dexmedetomidine — a sedative-type medication — in veterans and non-veterans who have both alcohol use disorder and PTSD, to see if it can help reduce alcohol cravings and stress-related symptoms. **You may be eligible if...** - You are between 21 and 65 years old - You can read and write in English - You have been diagnosed with alcohol use disorder (mild, moderate, or severe) - You have experienced a traumatic event that qualifies for PTSD criteria - You have a current PTSD symptom score above 15 on the PCL-5 scale - You have a normal heart rhythm (no significant EKG abnormalities) **You may NOT be eligible if...** - You have serious heart rhythm problems or cardiovascular disease - You have liver or kidney disease that could affect drug metabolism - You are currently dependent on opioids or other sedatives - You are pregnant or planning pregnancy - You have certain other psychiatric or neurological conditions that would make participation unsafe Talk to your doctor to see if this trial is right for you.