Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain - Phase II
The University of Texas Health Science Center, Houston
60 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session.
Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition
Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves).
Locations(1)
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NCT06968689