PET/MRI/EEG Imaging Study in Epilepsy
Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging
Massachusetts General Hospital
30 participants
Sep 21, 2023
OBSERVATIONAL
Conditions
Summary
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.
Eligibility
Inclusion Criteria2
- Age 18 or older
- Diagnosed with epilepsy with abnormal interictal EEG
Exclusion Criteria8
- Contraindications to PET, MRI, or EEG imaging
- History of severe brain disease such as stroke and head trauma
- History of brain surgery
- History of type I or II diabetes mellitus
- Fasting plasma glucose level >200 mg/dL
- Employed under direct supervision of the PI conducting the research
- Current use of drugs that modulate brain function
- Current or past history of major medical, neurological, or psychiatric conditions
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Interventions
Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.
Locations(1)
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NCT06974305