RecruitingNCT06984510

Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population

Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population: a Cohort Study


Sponsor

Ningbo No. 1 Hospital

Enrollment

2,720 participants

Start Date

Apr 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.


Eligibility

Min Age: 20 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is a retrospective data analysis (using existing health records, not enrolling new patients actively) that looks at whether biological aging — measured through blood test markers — is linked to a higher risk of developing type 2 diabetes in people who have metabolic-associated steatotic liver disease (MASLD, previously called non-alcoholic fatty liver disease). The goal is to better understand how aging biology contributes to diabetes risk. **You may be eligible if your records are included if...** - You had abdominal ultrasound data available from routine health check-ups - At least one standard metabolic measurement (BMI, blood pressure, triglycerides, HDL, or blood sugar) was recorded annually - You are between 20 and 90 years old at baseline **You may NOT be eligible if...** - Your liver condition was caused by alcohol or hepatitis B infection - You already had type 2 diabetes at baseline - Key baseline lab values were missing from your records Talk to your doctor to see if this study applies to you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERObservational

Observational


Locations(1)

the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000

Ningbo, Zhejiang, China

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NCT06984510


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