A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

This study is testing a new investigational drug called ALN-4324 to see if it can improve how well the body responds to insulin in adults with type 2 diabetes. ALN-4324 is a type of gene-silencing drug (called an RNA interference therapy) that targets a specific gene involved in insulin resistance. **You may be eligible if...** - You are an adult with a confirmed diagnosis of type 2 diabetes - Your BMI is between 25 and 39.9 (overweight to obese range) - Your HbA1c (a measure of long-term blood sugar control) is between 6.5% and 10.5% - You are currently on a stable dose of metformin **You may NOT be eligible if...** - You have serious medical conditions that could affect your safety or the study results - You are taking medications that interfere with blood sugar or insulin (other than your current diabetes treatment) - Additional protocol criteria may apply Talk to your doctor to see if this trial is right for you.