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RecruitingPhase 2NCT07465224

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

A Randomized, Double-blind, Placebo-controlled Study Investigating the Effect of ALN-4324 on Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus

Sponsor

Alnylam Pharmaceuticals

Enrollment

40 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

Type 2 Diabetes Mellitus (T2DM)

Summary

The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

  • Is an adult patient with a confirmed diagnosis of T2DM
  • Has a body mass index (BMI) of ≥25 kg/m\^2 and \<39.9 kg/m\^2
  • Has a hemoglobin A1c (HbA1c) ≥6.5% to \<10.5%
  • Is on a stable dose of metformin

Exclusion Criteria2

  • Has any clinically significant concomitant disease, medical condition, or abnormal laboratory finding that could compromise participant safety or confound interpretation of study results
  • Receiving therapies known to interfere with glucose or insulin metabolism other than current treatment for T2DM or birth control methods

Interventions

DRUGALN-4324

ALN-4324 will be administered subcutaneously (SC).

DRUGPlacebo

Placebo will be administered SC.

Locations(1)

Clinical Trial Site

Chula Vista, California, United States

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NCT07465224

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