Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma

This study is investigating whether mucus plugs in the airways of people with severe asthma are causing certain airway sections to not ventilate properly, and whether biologic medications can help clear these plugs and restore normal airflow. **You may be eligible if...** - You are 18–65 years old - You have a doctor's diagnosis of asthma for more than 1 year - You have elevated eosinophils (white blood cells) in your blood (over 300 cells/μL) and elevated FeNO (a marker of airway inflammation) - You have less than 10 pack-years of smoking history and have not smoked (including vapes, cigars, or marijuana) in the last 3 months - You have been approved to start dupilumab, tezepelumab, or benralizumab as part of your standard asthma care **You may NOT be eligible if...** - You had a respiratory infection in the past 4 weeks - Your BMI is above 30 - You had a recent asthma-related ER visit Talk to your doctor to see if this trial is right for you.