RecruitingPhase 3NCT06990321

Effectiveness of Medium-Dose Cytarabine Combined With Venetoclax for Consolidation Therapy in Elderly Patients With Intermediate to High-Risk Acute Myeloid Leukemia

A Single-center, Single-arm, Prospective Clinical Study of Intermediate-dose Cytarabine in Combination With Venetoclax for Consolidation Therapy of Middle- and High-risk Acute Myeloid Leukemia in The Elderly


Sponsor

Yehui Tan

Enrollment

68 participants

Start Date

Jun 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Single-center, Single-arm, Prospective Clinical Study of Intermediate-dose Cytarabine in Combination with Venetoclax for Consolidation Therapy of Middle- and High-risk Acute Myeloid Leukemia in the Elderly


Eligibility

Min Age: 60 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of chemotherapy drugs — cytarabine and venetoclax — as a consolidation treatment for older adults with acute myeloid leukemia (AML) who have already responded to initial treatment. **You may be eligible if...** - You are between 60 and 75 years old - You have been diagnosed with AML (a type of blood cancer) and achieved remission after initial chemotherapy - Your cancer is classified as intermediate or high risk - You are not a candidate for a bone marrow transplant - You have adequate liver, kidney, and heart function **You may NOT be eligible if...** - You are allergic to any of the drugs in the trial - Your leukemia has relapsed (more than 5% cancer cells in bone marrow) - You have another active cancer requiring treatment - You have severe liver, kidney, or heart problems - You have a history of drug or alcohol dependence Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIntermediate-dose Cytarabine in Combination with Venetoclax

Elderly patients with Middle- and High-risk Acute Myeloid Leukemia who received the Intermediate-dose Cytarabine in Combination with Venetoclax at the First Hospital of Jilin University from March 1, 2024 to December 31, 2026.


Locations(1)

The First Hospital of Jilin University

Changchun, Jilin, China

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NCT06990321


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