RecruitingNot ApplicableNCT07001631

Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease


Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Enrollment

40 participants

Start Date

Sep 20, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Children with sickle cell disease may experience frequent painful episodes. This, together with the traumatic experiences during a hospitalization, can lead to the development of posttraumatic stress reactions. As the stress can trigger painful episodes (pain crisis) in children with sickle cell disease, the investigators think that treating these stress symptoms can reduce the pain-related problems in their lives. Eye Movement Desensitization and Reprocessing (EMDR) is proven to be an effective trauma treatment for posttraumatic stress disorder. Research studies show that EMDR can reduce pain in adults. The investigators want to study now if EMDR effective is in reducing pain-related problems in children with sickle cell disease.


Eligibility

Min Age: 6 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether EMDR (Eye Movement Desensitization and Reprocessing) — a type of psychological therapy — can reduce pain-related interference in daily life for children with sickle cell disease (SCD), a blood disorder that causes episodes of severe pain. **You may be eligible if...** - Your child is between 6 and 18 years old and has a medical diagnosis of sickle cell disease - They report significant pain that interferes with daily activities (above a set clinical score) - They speak Dutch or English well enough to complete assessments **You may NOT be eligible if...** - Your child has had a successful stem cell transplant - Your child is pregnant - There are safety concerns at home (e.g., ongoing domestic violence) - Your child has an active serious psychiatric condition (such as psychosis or active suicidal risk) - Your child is already receiving psychological trauma therapy elsewhere - Your child has an estimated IQ below 80 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEREye Movement Desensitization and Reprocessing (EMDR)

The Dutch version of the standard EMDR protocol with age-specific adaptations for children and adolescents will be used. The eight phases consist of history taking, preparation, assessment, desensitization, installation, body scan, closure, and re-evaluation. During an EMDR session, the child focuses on emotionally disturbing memories (images, thoughts, emotions, and sensations) while simultaneously focusing on an external distracting stimulus (e.g., eye movements). This process facilitates accessing and desensitizing the traumatic memory network, so information processing is enhanced, and new associations can be made between the traumatic memory and more adaptive memories and information. As a result, the traumatic memory representation will be less intense and emotionally disturbing. After the intake session (week 1), including case conceptualization and treatment plan, a maximum of 6 weekly EMDR sessions with a duration of 1 hour per session will be offered.


Locations(1)

Amsterdam UMC

Amsterdam, Netherlands

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NCT07001631


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