Ischemic Preconditioning in Osteoarthritis and Back Pain
University of Illinois at Chicago
24 participants
Sep 12, 2025
INTERVENTIONAL
Conditions
Summary
We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.
Eligibility
Inclusion Criteria4
- Reported Knee Pain using ACR Criteria
- Reported Back Pain using ODI Criteria > 12
- Ability to walk for at least 3 minutes without the use of aids
- Ability to provide written informed consent
Exclusion Criteria10
- Younger than 50 years old
- History of Knee or Hip Replacements
- History of steroid injection within the previous 6 months
- Presence of neuromuscular joint condition that affects lower extremity function
- History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
- History of heart failure or thrombosis
- Allergic to ultrasound gel
- History of spine surgery
- Non-English speaker
- Currently pregnant or intends to become pregnant during the study
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Interventions
The intervention arm will include full blood flow occlusion in one thigh for 5 minutes followed by 5 minutes of reperfusion for a cycle of 50 minutes.
This intervention includes 25mmHg of pressure, which is not sufficient for blodo flow occlusion.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07003113