Recombinant Human IL-21-expressing Oncolytic Vaccinia Virus Injection (hV01) in Advanced Pancreatic Cancer

This study is testing a new type of treatment for advanced pancreatic cancer — an oncolytic vaccinia virus (a modified virus that infects and kills cancer cells) that also expresses a protein called IL-21 to boost the immune response. The virus is injected directly into the tumor using an endoscope. **You may be eligible if...** - You are between 18 and 75 years old - You have advanced pancreatic cancer confirmed by biopsy that has not responded to standard treatments - You have at least one tumor larger than 1.5 cm that can be injected (directly or via endoscopy) - Your overall health is good (ECOG 0–1) - Your blood counts, liver, and kidney function meet required levels **You may NOT be eligible if...** - You have not yet tried standard treatments for pancreatic cancer - You have poor overall health (ECOG 2 or above) - Your tumor cannot be safely injected - You are pregnant or breastfeeding - Your organ function does not meet study thresholds Talk to your doctor to see if this trial is right for you.