RecruitingEarly Phase 1NCT07416240

Exploratory Clinical Study of Claudin18.2-Targeted Activated DC and CAR-T Therapy in Advanced Pancreatic Cancer.

Exploratory Clinical Study of Combined Claudin18.2-Targeted Activated DC and CAR-T Therapy in Patients With Advanced Pancreatic Cancer

Sponsor

Hainan Cancer Hospital

Enrollment

10 participants

Start Date

Feb 18, 2026

Study Type

INTERVENTIONAL

Conditions

Advanced Pancreatic Cancer

Summary

This is an open-label, single-arm clinical study designed to evaluate the safety and preliminary efficacy of Claudin18.2 Targeted Activated DC combined with CAR-T therapy in patients with Advanced Pancreatic Cancer. This combination therapy activates dendritic cells (DCs) to precisely target the tumor site, reshaping the tumor immune microenvironment, breaking down the immunosuppressive barrier, and allowing CAR-T cells to penetrate deeper into the tumor more efficiently, precisely and persistently killing cancer cells.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination of two experimental treatments for advanced pancreatic cancer: specially trained immune cells called dendritic cells (DC) that are designed to target a protein called Claudin18.2, and CAR-T cell therapy (genetically modified immune cells programmed to attack cancer cells carrying the same protein). **You may be eligible if...** - You are 18 to 80 years old - You have advanced pancreatic cancer confirmed by biopsy - Your tumor has at least one measurable lesion - Your cancer has Claudin18.2 expression **You may NOT be eligible if...** - You have already tried multiple prior therapies or are in very poor health - Your tumor does not express the Claudin18.2 protein - You have other serious health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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