RecruitingPhase 1NCT07011004

A Study of Natural Killer Cells in Combination With Atezolizumab in People With Acute Myelogenous Leukemia

Phase I Study of Cytokine Induced Memory-Like Natural Killer Cells Combined With Atezolizumb in Subjects With Relapsed or Refractory Acute Myelogenous Leukemia


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

18 participants

Start Date

May 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The researchers are doing this study is to find the highest dose of cytokine-induced memory-like (CIML) natural killer (NK) cells in combination with the drug atezolizumab that causes few or mild side effects in people with relapsed/refractory acute myelogenous leukemia (AML). The researchers will also look at whether the treatment combination works against participants' cancer.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a combination of natural killer (NK) cell therapy — immune cells engineered to fight cancer — together with an immunotherapy drug called atezolizumab, for patients with acute myeloid leukemia (AML) that has not responded to prior treatment. **You may be eligible if...** - You have been diagnosed with AML confirmed by bone marrow biopsy - Your leukemia has either failed to respond to at least 2 prior rounds of chemotherapy, OR has relapsed after a stem cell transplant - You are in reasonably good physical condition **You may NOT be eligible if...** - You have active leukemia in the brain or spinal fluid - You have had a stem cell transplant within the past 3 months or have active graft-versus-host disease - You have uncontrolled infection or significant organ failure - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BIOLOGICALCytokine Induced Memory-Like Natural Killer Cells

Subjects will receive subcutaneous recombinant human IL-2 (rh-IL2) every other day x 6 doses beginning on day 0 via subcutaneous injection.

BIOLOGICALAtezolizumb

Single dose of Atezolizumab IV over 60 minutes IV.

BIOLOGICALCIML-NK cell therapy

CIML-NK cell therapy as an intravenous (IV) infusion


Locations(7)

Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth (Limited protocol activities)

Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, United States

Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities)

Commack, New York, United States

Memorial Sloan Kettering West Harrison (Limited Protocol Activities)

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Memorial Sloan Kettering Nassau (Limited Protocol Activites)

Rockville Centre, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07011004


Related Trials