A Study of CD371-YSNVZIL-18 CAR T Cells in People With Acute Myeloid Leukemia

This study tests a new type of immune cell therapy called CAR T-cell therapy — specifically targeting a protein called CD371 — in people with acute myeloid leukemia (AML, a blood cancer) whose disease has not responded to standard treatments or has come back after treatment. **You may be eligible if...** - You have AML that carries the CD371 protein on cancer cells - Your leukemia has come back or has not responded to prior standard chemotherapy - You have adequate heart and organ function - You are willing to provide samples for research **You may NOT be eligible if...** - You are pregnant, breastfeeding, or not using contraception - You have active, uncontrolled brain involvement from leukemia - You have HIV, active Hepatitis B or C infection - You have severe heart problems (like heart failure or recent heart attack) - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.