Evaluation of Tau-Pathology in Sporadic and LRRK2 Parkinson's Disease

This study is using advanced PET brain scans to measure a protein called tau in people with Parkinson's disease — both with and without a specific genetic type (LRRK2 mutation) — to understand how tau buildup may contribute to the disease. **You may be eligible if...** - You are between 45 and 85 years old - You have been diagnosed with Parkinson's disease (either sporadic or LRRK2-related) - Women must be post-menopausal, surgically sterile, or using a reliable contraceptive method **You may NOT be eligible if...** - You are pregnant or could become pregnant and are not using contraception - You have metal implants or other factors that prevent brain scanning - You have a significant other neurological condition beyond Parkinson's Talk to your doctor to see if this trial is right for you.