Comparison of Dexmedetomidine + Ketamine for Postoperative Pain in C-Section
Comparison of Different Doses of Dexmedetomidine in Combination With Ketamine for Control of Post-Operative Pain in Lower Segment Caesarean Section Surgeries
Fatima Memorial Hospital
90 participants
May 16, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to compare three different doses of dexmedetomidine, when combined with a fixed dose of ketamine, for pain control in women undergoing cesarean section. The goal is to find the most effective combination with the fewest side effects.
Eligibility
Inclusion Criteria3
- Elective lower segment cesarean section
- American Society of Anesthesiologists (ASA) Physical Status II
- Provided informed consent
Exclusion Criteria4
- Known drug allergy
- Presence of significant comorbidities
- Emergency surgery
- Documented psychiatric illness
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Interventions
Dexmedetomidine infusion at one of the following doses: Group A: 0.2 µg/kg/hr Group B: 0.3 µg/kg/hr Group C: 0.4 µg/kg/hr Route of Administration: Intravenous Frequency: Continuous infusion during postoperative period
Ketamine infusion at a fixed dose of 0.25 mg/kg/hr administered in all three groups. Route of Administration: Intravenous Frequency: Continuous infusion during postoperative period
Locations(1)
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NCT07022821