RecruitingPhase 1NCT07026760

Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals

Sponsor

Universidade Federal de Pernambuco

Enrollment

18 participants

Start Date

Oct 1, 2022

Study Type

INTERVENTIONAL

Conditions

Healthy Individuals

Summary

This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how different settings — specifically different frequencies (1 Hz, 10 Hz, and 25 Hz) and intensities — of trans-spinal magnetic stimulation (TsMS), a non-invasive technique that applies magnetic pulses to the spine, affect brain excitability in healthy adults. Understanding the brain's response to these stimulation parameters could help researchers design better non-invasive treatments for neurological conditions in the future. Healthy right-handed adults aged 18 to 40, including women on consistent hormonal contraception, are eligible, while those who are pregnant, have a history of epilepsy, have metal implants, or have neurological conditions are excluded. Participants will receive multiple sessions of TsMS at the neck region under a randomized crossover design and have brain responses measured before and after each session. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETrans-spinal magnetic stimulation (90% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (100% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (110% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (90% + 10 Hz)

High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (100% MT + 10 Hz)

High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (110% MT + 10 Hz)

High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (90% MT + 25 Hz)

High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (100% MT + 25 Hz)

High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (110% MT + 25 Hz)

High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

Locations(1)

Universidade Federal de Pernambuco

Recife, Pernambuco, Brazil

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NCT07026760

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