RecruitingPhase 1NCT07026760

Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals

Sponsor

Universidade Federal de Pernambuco

Enrollment

18 participants

Start Date

Oct 1, 2022

Study Type

INTERVENTIONAL

Conditions

Healthy Individuals

Summary

This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria1

Healthy adults aged 18-40 years, of both sexes; right-handed (confirmed via the Edinburgh Handedness Inventory); and for women, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability.

Exclusion Criteria1

Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions that could interfere with assessments or interventions; or use of substances that alter nervous system excitability.

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Interventions

DEVICETrans-spinal magnetic stimulation (90% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (100% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (110% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (90% + 10 Hz)

High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (100% MT + 10 Hz)

High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (110% MT + 10 Hz)

High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (90% MT + 25 Hz)

High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (100% MT + 25 Hz)

High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICETrans-spinal magnetic stimulation (110% MT + 25 Hz)

High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

Locations(1)

Universidade Federal de Pernambuco

Recife, Pernambuco, Brazil

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NCT07026760

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