Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity
Nantes University Hospital
40 participants
Jul 15, 2025
INTERVENTIONAL
Conditions
Summary
Disruption of white adipose tissue (WAT) homeostasis during obesity is central to the development of associated cardiometabolic complications. Dietary supplementation with oleic acid in obese patients can limit these complications. Experimental data, obtained in preclinical models, suggest that the beneficial effects of oleic acid may protect the TAB by increasing cholesterol esterification. The NAMICO study aims to test this hypothesis using TAB biopsies collected from obese patients undergoing bariatric surgery who had previously undergone dietary enrichment with either a conventional oil or an oil rich in oleic acid.
Eligibility
Plain Language Summary
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Interventions
Nutritional intervention for 13 weeks ± 2 weeks, including 40 millilitres of sunflower oil rich in oleic acid
Nutritional intervention for 13 weeks ± 2 weeks, including 40 millilitres of conventional sunflower oil
Locations(1)
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NCT07027033