RecruitingPhase 2NCT07028749

Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Phase 2b Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of MAR001 in Patients With Elevated Triglycerides and Remnant Cholesterol (TYDAL-TIMI 78)

Sponsor

Marea Therapeutics

Enrollment

316 participants

Start Date

Jun 30, 2025

Study Type

INTERVENTIONAL

Conditions

Hypertriglyceridemia

Summary

The primary objective of the study is to evaluate the effect of MAR001 compared to placebo on levels of TG in adults with elevated TG and RC.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called MAR001 and a drug called Placebo for people with hypertriglyceridemia. The study is currently recruiting participants at 54 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMAR001

Subcutaneous Injection

DRUGPlacebo

Subcutaneous injection

Locations(55)

Marea Site 328

Anniston, Alabama, United States

Marea Site 329

Mobile, Alabama, United States

Marea Site 313

Little Rock, Arkansas, United States

Marea Site 306

Hamden, Connecticut, United States

Marea Site 302

Boca Raton, Florida, United States

Marea Site 307

Port Saint Lucie, Florida, United States

Marea Site 310

Columbus, Georgia, United States

Marea Site 319

Peachtree Corners, Georgia, United States

Marea Site 317

Park Ridge, Illinois, United States

Marea Site 325

Springfield, Illinois, United States

Marea Site 301

Louisville, Kentucky, United States

Marea Site 316

Baltimore, Maryland, United States

Marea Site 330

Kansas City, Missouri, United States

Marea Site 305

St Louis, Missouri, United States

Marea Site 304

Great Neck, New York, United States

Marea Site 318

New Windsor, New York, United States

Marea Site 303

Greensboro, North Carolina, United States

Marea Site 315

Winston-Salem, North Carolina, United States

Marea Site 314

Greenville, South Carolina, United States

Marea Site 320

Little River, South Carolina, United States

Marea Site 326

Memphis, Tennessee, United States

Marea Site 322

Amarillo, Texas, United States

Marea Site 308

McKinney, Texas, United States

Marea Site 312

San Antonio, Texas, United States

Marea Site 321

Manassas, Virginia, United States

Marea Site 309

Tacoma, Washington, United States

Marea Site 103

Canberra, Australian Capital Territory, Australia

Marea Site 105

Kanwal, New South Wales, Australia

Marea Site 107

Merewether, New South Wales, Australia

Marea Site 106

Miranda, New South Wales, Australia

Marea Site 109

Wollongong, New South Wales, Australia

Marea Site 108

Herston, Queensland, Australia

Marea Site 104

Milton, Queensland, Australia

Marea Site 111

Leabrook, South Australia, Australia

Marea Site 102

Clayton, Victoria, Australia

Marea Site 110

Heidelberg Heights, Victoria, Australia

Marea Site 113

Hoppers Crossing, Victoria, Australia

Marea Site 101

Nedlands, Western Australia, Australia

Marea Site 112

Perth, Western Australia, Australia

Marea Site 406

Concord, Ontario, Canada

Marea Site 403

London, Ontario, Canada

Marea Site 404

Sarnia, Ontario, Canada

Marea Site 401

Chicoutimi, Quebec, Canada

Marea Site 402

Montreal, Quebec, Canada

Marea Site 405

Québec, Quebec, Canada

Marea Site 407

Québec, Quebec, Canada

Marea Site 211

Birkenhead, Auckland, New Zealand

Marea Site 207

New Lynn, Auckland, New Zealand

Marea Site 203

Papatoetoe, Auckland, New Zealand

Marea Site 205

Silverdale, Auckland, New Zealand

Marea Site 206

Christchurch, South Island, New Zealand

Marea Site 204

Ebdentown, Upper Hutt, New Zealand

Marea Site 209

Christchurch, New Zealand

Marea Site 202

Christchurch, New Zealand

Marea Site 208

Rotorua, New Zealand

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NCT07028749

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Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Conditions

Summary

Eligibility

Plain Language Summary

Interventions

Locations(55)

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